GC × GC-QMS/FID
Quantitative determination of 54 allergens in raw fragrances by comprehensive Two-Dimensional Gas Chromatography coupled to quadrupole Mass Spectrometry and Flame Ionization Detection (GC×GC-QMS/FID): a reliable approach for routine laboratories
The analytical method is based on gas chromatography and mass spectrometry (GC-MS) and is capable to detect and to quantify about 60 fragrance substances and major isomers at a concentration higher than 0.002% (20 mg/kg) in ready to inject fragrance raw materials.
To match routine laboratory control requirements in term of rapidity and reliability of the results, comprehensive twodimensional gas chromatography hyphenated with robust and low-cost quadrupole mass spectrometry (GC×GC-QMS) represent a strategic choice
In the present study it was adopted a looptype
thermal modulator (KT 2004 Zoex Corporation, Houston, TX) with liquid nitrogen as cryogenic fluid; systems based on the same modulation dynamics but avoiding cryogenic
fluids are equipped with chill units – ZX2 Zoex. These solutions are fully compatible with allergens volatility for an effective trapping.